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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKL
All Species:
22.42
Human Site:
S255
Identified Species:
41.11
UniProt:
P17858
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.42
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17858
NP_002617.3
780
85018
S255
G
E
T
R
S
R
G
S
R
L
N
I
I
I
I
Chimpanzee
Pan troglodytes
XP_001150233
780
84936
S255
G
E
T
R
S
R
G
S
R
L
N
I
I
I
I
Rhesus Macaque
Macaca mulatta
XP_001096244
851
93251
S326
S
E
T
R
T
R
G
S
R
L
N
I
I
I
V
Dog
Lupus familis
XP_544922
751
82459
K243
G
A
I
D
R
N
G
K
P
I
S
S
R
Y
V
Cat
Felis silvestris
Mouse
Mus musculus
P12382
780
85282
S255
G
E
T
R
S
R
G
S
R
L
N
I
I
I
I
Rat
Rattus norvegicus
P30835
780
85320
S255
G
E
T
R
S
R
G
S
R
L
N
I
I
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514123
751
82475
K243
G
A
I
D
R
N
G
K
P
I
S
S
N
Y
V
Chicken
Gallus gallus
XP_001232621
780
85127
S255
G
E
T
R
S
R
G
S
R
L
N
I
I
I
I
Frog
Xenopus laevis
NP_001091319
786
86623
K256
S
E
N
R
A
R
K
K
R
L
N
I
I
I
V
Zebra Danio
Brachydanio rerio
XP_698635
780
84600
C255
E
E
S
R
S
K
G
C
R
L
N
I
I
I
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52034
788
86630
Q257
A
Q
E
R
S
A
G
Q
R
L
N
I
V
I
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27483
756
83282
K248
G
S
V
R
K
M
G
K
R
Q
N
V
I
I
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P16862
959
104599
K438
S
K
H
R
S
R
G
K
R
T
T
I
V
V
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
63.8
90.1
N.A.
94
94.2
N.A.
86.6
86.7
68.4
77.5
N.A.
55.5
N.A.
40.1
N.A.
Protein Similarity:
100
99.6
77.3
93
N.A.
97.1
97.3
N.A.
91.9
93.8
83.7
89.6
N.A.
73
N.A.
58.2
N.A.
P-Site Identity:
100
100
80
13.3
N.A.
100
100
N.A.
13.3
100
60
73.3
N.A.
53.3
N.A.
46.6
N.A.
P-Site Similarity:
100
100
93.3
33.3
N.A.
100
100
N.A.
33.3
100
73.3
86.6
N.A.
73.3
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
36.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
0
0
8
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
62
8
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
62
0
0
0
0
0
93
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
16
0
0
0
0
0
0
16
0
77
70
77
47
% I
% Lys:
0
8
0
0
8
8
8
39
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
70
0
0
0
0
8
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
16
0
0
0
0
77
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
8
0
8
0
0
0
0
0
% Q
% Arg:
0
0
0
85
16
62
0
0
85
0
0
0
8
0
0
% R
% Ser:
24
8
8
0
62
0
0
47
0
0
16
16
0
0
0
% S
% Thr:
0
0
47
0
8
0
0
0
0
8
8
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
0
0
0
8
16
8
47
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _